Endocrine Abstracts

Introduction: An accurate identification of affected parathyroid is crucial for implementation of mini-invasive surgery techniques and therefore reduction of complication rate. A few centers postulate measuring washout parathormone (PTH)concentrationin suspected lesions, despite lack of established cut-off point for concentration values and validated measurement methods. Thisprospective study aimed to compare washout PTH assessment vs MIBI scintiscan in terms of efficacy in lo...

Background: Selenium (Se) sufficiency is beneficial for thyroid metabolism and pregnancy course due to its antioxidant and anti-inflammatory properties. As a part of selenoenzymes, it ameliorates autoimmune thyroid disease (AITD) progression in mothers and provides proper neurogenesis in fetuses. Despite lacking or conflicting recommendations for its supplementation in pregnancy, Se is used in a clinical setting, as a common constituent of multivitamin pregnancy diet supplemen...

Introduction: Hepcidin is a reactive inflammatory protein, responsible for ferrum homeostasis. Its concentration was already measured in hyperthyroiditis in the course of Graves disease and after restoration of euthyroidism, but also in growth hormone deficiency, hyperprolactinemia, however no significant changes were noted. De Quervain thyroiditis is a rare type of subacute thyroid inflammation, caused by interplay of unknown infectious, genetic and autoimmune factors and res...

Introduction: Hepcidin is an acute-phase protein and a key regulator of iron homeostasis. Anemia frequently occurs in patients with hyperthyroidism, while hepcidin may be a potential link.Objectives: Prospective evaluation of hepcidin serum concentration and other parameters related to Fe homeostasis in group of hyperthyroid patients in the course of Graves’ disease (GD) at diagnosis and after restoration of euthyroidism.Pati...

IntroductionHepcidin, main body iron regulator protein, decreases iron concentration available for erythropoiesis. Oppositely, excessive erythropoiesis in acromegaly patients (increased GH and IGF-1), may inhibit hepcidin production. GH stimulates bone marrow, whereas IGF-1 receptors are expressed in erythrocytes. Exogenous GH administration in healthy subjects reduced hepcidin level. The role of hepcidin in iron metabolism of acromegaly patients has not...

Background: ACTH-Independent Macronodular Adrenal Hyperplasia (AIMAH) is usually manifested as both-sided adrenal incidentalomas with subclinical overproduction of cortisol (<2% of Cushing’s syndrome). The pathogenesis involves genetic factors, expression of adrenal aberrant hormone receptors and paracrine adrenal corticotropin (ACTH) secretion. Treatment is usually bilateral adrenalectomy, but in some cases also unilateral adrenalectomy or pharmacologic therapy can b...

Background: Pregnancy is a state of a higher iodine intake demand. Proper iodine status is important during pregnancy for fetal neurodevelopment and maternal thyroid function. Urinary iodine concentration (UIC) is the most common indicator of iodine status.Objectives: The aim of this study was to develop and validate a novel ion-pair HPLC-UV method to measure iodine in urine and to assess iodine status in pregnant women.Methods: Sa...

Background: Iodine deficiency disorders are a global health problem partially eliminated by salt iodization national programmes. In Poland, this micronutrient shortage diminished over the last two decades, however in some particularly vulnerable groups like pregnant and breastfeeding women additional supplementation of iodine is beneficial for both mother and newborn. The programme’s effectiveness should be regularly evaluated. The matter of concern remains the optimal re...

IntroductionTwenty-four years after implementing the national salt iodization programme in Poland in 1997, the country is considered as adequate iodine supply. However, most reports do not take into consideration pregnant or lactating females. Additional intake of 150–200 µg KI per day, independently on levothyroxine (LT4) treatment, is a recommended dose for pregnancy and lactation due to Polish endocrinological guidelines. The study aim was t...

Objective: The thyroid fine needle aspiration biopsy (FNAB) may bring inconclusive cytological results of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) or follicular neoplasm/suspicious for follicular neoplasm (FN/SFN). The objective of the study was to describe the genetic landscape of indeterminate thyroid nodules to better understand this phenomenon and identify genetic markers potentially differentiating benign and malignant ...